Stevia Studies - Research About Stevia

Effect of Steviol on para-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubule 2001

A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension 2000

JOINT FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES, 17-26 June 2008

Boonkaewwan C, Toskulkao C, Vongsakul M. Anti-inflammatory and immunomodulatory activities of stevioside and its metabolite steviol on THP-1 cells. Journal of Agricultural and Food Chemistry. 2006;54(3):785-789.

Braguini WL, Gomes MA, de Oliveira BH, Carnieri EG, Rocha ME, de Oliveira MB. Activity of isosteviol lactone on mitochondrial metabolism. Toxicology Letters. 2003;143(1):83-92.

Chang JC, Wu MC, Liu IM, Cheng JT. Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats. Hormone Metabolism Research. 2005;37(10):610-616.

Abudula R, Jeppesen PB, Rolfsen SE, Xiao J, Hermansen K. Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency. Metabolism. 2004;53(10):1378-1381.

Chen J, Jeppesen PB, Nordentoft I, Hermansen K. Stevioside counteracts the glyburide-induced desensitization of the pancreatic beta-cell function in mice: studies in vitro. Metabolism. 2006;55(12):1674-1680.

Columbus M. The cultivation of stevia, "nature's sweetener". Ministry of Agriculture and Food. The Government of Ontario, Canada. Available at: http://www.omafra.gov.on.ca/english/crops/facts/stevia.htm

Ferreira EB, de Assis Rocha Neves F, da Costa MA, do Prado WA, de Araujo Funari Ferri L, Bazotte RB. Comparative effects of Stevia rebaudiana leaves and stevioside on glycaemia [sic] and hepatic gluconeogenesis. Planta Medica. 2006;72(8):691-696.

Ferri LA, Alves-Do-Prado W, Yamada SS, Gazola S, Batista MR, Bazotte RB. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytotherapy Research. 2006;20(9):732-736.

Gardana C, Simonetti P, Canzi E, Zanchi R, Pietta P. Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. Journal of Agricultural and Food Chemistry. 2003;51(22):6618-6622.

Geuns JM. Stevioside. Phytochemistry. 2003;64(5):913-921.

Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004;53(1):73-76.

Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clinical Therapeutics. 2003;25(11):2797-2808.

Hsu YH, Liu JC, Kao PF, Lee CN, Chen YJ, Hsieh MH, Chan P. Antihypertensive effect of stevioside in different strains of hypertensive rats. Zhonghua Yi Xue Za Zhi (Taipei). 2002;65(1):1-6.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Metabolism, 2000;49(2):208-214.

Jeppesen PB, Gregersen S, Rolfsen SE, et al. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 2003;52(3):372-378.

Koyama E, Kitazawa K, Ohori Y, et al. In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food Chemistry and Toxicology. 2003;41(3):359-374.

Koyama E, Sakai N, Ohori Y, et al. Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food Chemistry and Toxicology. 2003;41(6):875-883.

Lailerd N, Saengsirisuwan V, Sloniger JA, Toskulkao C, Henriksen EJ. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. Metabolism. 2004;53(1):101-107.

Lee CN, Wong KL, Liu JC, Chen YJ, Cheng JT, Chan P. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Medica. 2001;67(9):796-799.

Liu JC, Kao PK, Chan P, et al. Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. Pharmacology. 2003;67(1):14-20.

Matsukubo T, Takazoe I. Sucrose substitutes and their role in caries prevention. International Dental Journal. 2006;56(3):119-130.

Nunes AP, Ferreira-Machado SC, Nunes RM, Dantas FJ, De Mattos JC, Caldeira-de-Araujo A. Analysis of genotoxic potentiality of stevioside by comet assay. Food Chemistry and Toxicology. 2007;45(4):662-666.

Raskovic A, Gavrilovic M, Jakovljevic V, Sabo J. Glucose concentration in the blood of intact and alloxan-treated mice after pretreatment with commercial preparations of Stevia rebaudiana (Bertoni). European Journal of Drug Metabolism and Pharmacokinetics. 2004;29(2):87-90.

Raskovic A, Jakovljevic V, Mikov M, Gavrilovic M. Joint effect of commercial preparations of Stevia rebaudiana Bertoni and sodium monoketocholate on glycemia in mice. European Journal of Drug Metabolism and Pharmacokinetics. 2004;29(2):83-86.

Sekihashi K, Saitoh H, Sasaki Y. Genotoxicity studies of stevia extract and steviol by the comet assay. [Article in Japanese] Journal of Toxicological Sciences. 2002;27(Suppl 1):1-8.

Temcharoen P, Suwannatrai M, Klongpanichpak S, Apibal S, Glinsukon T, Toskulkao C. Evaluation of the effect of steviol on chromosomal damage using micronucleus test in three laboratory animal species. Journal of the Medical Association of Thailand. 2000;83(Suppl 1):S101-S108.

Terai T, Ren H, Mori G, Yamaguchi Y, Hayashi T. Mutagenicity of steviol and its oxidative derivatives in Salmonella typhimurium TM677. Chemical and Pharmaceutical Bulletin (Tokyo). 2002;50(7):1007-1010.

Tomita T, Sato N, Arai T, et al. Bactericidal activity of a fermented hot-water extract from Stevia rebaudiana Bertoni towards enterohemorrhagic Escherichia coli O157:H7 and other food-borne pathogenic bacteria. Microbiology and Immunology. 1997;41(12):1005-1009.

Toskulkao C, Chaturat L, Temcharoen P, Glinsukon T. Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species. Drug and Chemical Toxicology. 1997;20(1-2):31-44.

Toskulkao C, Sutheerawatananon M, Wanichanon C, Saitongdee P, Suttajit M. Effects of stevioside and steviol on intestinal glucose absorption in hamsters. Journal of Nutritional Science and Vitaminology. (Tokyo) 1995;41(1):105-113.

U.S. Food and Drug Administration. Import Alert. Automatic detention of stevia leaves, extract of stevia leaves, and food containing stevia. Updated October 27, 2005. Available at: http://www.fda.gov/ora/fiars/ora_import_ia4506.html. Accessed October 17, 2006.

Wong KL, Lin JW, Liu JC, et al. Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. Pharmacology. 2006;76(4):163-169.

Wong KL, Chan P, Yang HY, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sciences. 2004;74(19):2379-2387.

Wong KL, Yang HY, Chan P, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Medica. 2004;70(2):108-112.

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